Our Markets of Opportunity

Our current efforts are focused on creating in vitro diagnostic and imaging tests for Alzheimer’s Disease and other neurodegenerative diseases. Though increasingly prevalent, Alzheimer’s Disease is currently a “diagnosis of exclusion” as disease progression rules out other potential causes. Using Adlyfe’s unique technology that detects both the sequence and the conformation of amyloid proteins, our goal is to create sensitive and specific detection methods that allow early stage diagnosis and disease progression monitoring.

Clinical Diagnostics: We anticipate expanded clinical testing of people in various stages of disease will present an opportunity to provide an amyloid screening panel that will determine the level of misfolded protein targets against a number of protein misfolding diseases providing an early screening test for the likelihood of disease progression.

Drug Development and Companion Diagnostics: Our test for amyloid formation as a biomarker will be a valuable companion diagnostic for developing new Alzheimer's drugs that affect amyloid formation and allow faster, more efficient clinical trial management of patients and to monitor their progression in drug therapy. We anticipate future clinical trials to correlate our screening test with the likelihood of disease during the progression of Alzheimer's.

Prion Diseases: We have demonstrated the utility of our test in detecting animal prion misfolded protein in blood in various stages of Transmissible Spongiform Encephalopathy (TSE, or “mad cow” disease). While there are currently TSE post-mortem tests that only can detect in tissue in late stage disease, our assay will enable monitoring the human blood supply or live animal testing of cows and other animals before symptoms occur. The considerable number of animal by-products used in pharmaceuticals and in cell culture research (bovine serum, gelatins) and their possible contamination through processing of infected animals also presents a significant opportunity for Adlyfe's unique test.

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